Marigot man pleads guilty to murdering grandmother
Trump says he wouldnt allow US to use Kim family as assets
That sinking feeling Water table dip and how Punjab must fight the
reMarkables Pricey PaperLike Tablet Ready to Ship
With Custom Skills Alexa Inches Closer to Being One of the Family
Nvidias Turing Chip Opens Door to New Virtual Reality Realm
TGFbeta signaling pathway in uterine cells protects against cancer
Light physical activity may lower risk of cardiovascular disease in older women
Study highlights the need for psychiatric care to be integrated into cancer
Auburn study explains link between habitat loss and global emergence of infectious
Research opens door to better treatment for common cause of diarrhea
Google selfdriving van involved in crash in Arizona driver injured Update
Airbus warns could leave UK if no Brexit deal
Chips are down for online gamblers as US moves toward new ban
Instagram moves into ecommerce with shopping button
Dozens of Pilot Whales Washed Up on Georgia Beach and Beachgoers Came
Amazon Prime Day Best Health Fitness Deals
Massive HumanSize Jellyfish Stuns Divers Off the Coast of England
Nikah halala petitioner seeks protection from SC after acid attackNikah halala petitioner
AP to hand over buildings inHyderabad to Telangana

Marigot man pleads guilty to murdering grandmother

first_imgShareTweetSharePinLahanson Javeed Pascal has pleaded guilty to the 2013 murder of his grandmother in Marigot.Flora Pascal, 82, was found by her son in an unconscious state and bleeding from wounds to her head, at her home around 2:00 pm on April 7, 2013.She was taken to Marigot Hospital where she was treated and then transferred to the Princess Margaret Hospital (PMH) where she was admitted to the Intensive Care Unit (ICU).Lahanson Javeed Pascal then aged 17, was arrested and charged with grievous bodily harm.However, the charge was changed to murder after Flora Pascal died on April 22, 2013  at the ICU of the PMH. Sentencing is set for June 14, 2019 after a social inquiry report.last_img read more

Trump says he wouldnt allow US to use Kim family as assets

first_img US House rejects Saudi weapons sales; Trump to veto By AP | Published: June 12, 2019 11:05:05 am Kulbhushan Jadhav ‘guilty of crimes’, will proceed further as per law: Imran Khan Hold the applause until Hafiz Saeed is convicted: US committee to Donald Trump Advertising Trump says he wouldn't allow US to use Kim family as assets FILE — President Donald Trump and North Korean leader Kim Jong Un at their meeting in Hanoi, Vietnam (Doug Mills/The New York Times)President Donald Trump said Tuesday that he would not approve of U.S. intelligence agencies using family members of North Korean leader Kim Jong Un as assets, a day after a report that Kim’s half brother had traveled to Malaysia to meet his CIA contact before being assassinated there in 2017. Related News Virat Kohli won’t have a say in choosing new coach Kim Jong Nam was the eldest son in the current generation of North Korea’s ruling family and could have been seen as a threat to Kim Jong Un’s rule.The Journal said Kim Jong Nam met on several occasions with CIA operatives, but also that many details of his relationship with the agency remain unclear.The CIA declined to comment on the story.Kim Jong Nam was killed on Feb. 13, 2017, when two young women smeared VX nerve agent on his face at a Kuala Lumpur International Airport terminal.Murder charges were dropped against the women earlier this year. They had been accused of colluding with four North Koreans who prosecutors said had fled the country the day of the attack.Lawyers for the women have said they were pawns in a political assassination with clear links to the North Korean Embassy in Kuala Lumpur. The U.S. and South Korea also have blamed North Korea, but Malaysian officials never officially accused Pyongyang of involvement.center_img Unbowed, Trump intensifies attacks on four Democratic congresswomen LiveKarnataka floor test: Will Kumaraswamy’s 14-month-old govt survive? Advertising The lack of substance and fruitless working-level talks set up the collapse of the second Trump-Kim meeting in February, which the Americans blamed on North Korea’s excessive demands for sanctions relief in exchange for only a partial surrender of its nuclear capabilities.The North has since expressed its displeasure by resuming short-range missile tests and issuing belligerent rhetoric toward Washington and Seoul. Kim has said the United States has until the end of the year to offer mutually acceptable terms for a deal to salvage the diplomacy.On Tuesday, officials at South Korea’s National Intelligence Service and Unification Ministry, which oversees ties with North Korea, said they couldn’t confirm the report on Kim Jong Nam.While Kim Jong Nam spent much of his life abroad after falling out of favor with his family, he was constantly aware of the monitoring presence of Pyongyang and obsessed by fears that he would get assassinated, South Korean officials have said. Following his death, the NIS told South Korean lawmakers that North Korea had tried for several years to kill him and that he sent a letter to Kim Jong Un in 2012 begging for the lives of himself and his family. 0 Comment(s) Trump said he was aware of the report on Kim Jong Nam’s alleged contacts with U.S. intelligence published Monday by The Wall Street Journal, which cited a “person knowledgeable about the matter.” The U.S. president said his message to the North Korean leader would be that, “I wouldn’t let that happen under my auspices.”Trump’s comments came as he continued to lavish praise on Kim Jong Un, who has aggressively pursued a nuclear weapons program while running a government accused of brutal human rights abuses, even after a breakdown in their nuclear talks earlier this year in Vietnam. Trump, who said he had “just received a beautiful letter” from Kim, said Kim had kept his word in halting tests of nuclear weapons and long-range ballistic missiles.Following a provocative run in weapons tests, Kim initiated diplomacy with Seoul and Washington in 2018, which led to three summits with South Korea’s president and his first meeting with Trump in Singapore last June, where they issued a vague statement on a nuclear-free Korean Peninsula without describing how and when it would occur. Best Of Express last_img read more

That sinking feeling Water table dip and how Punjab must fight the

first_img Health ranking: Tamil Nadu objects, NITI says any relook only next year Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Budget boost for Electric Vehicles will give India a first mover advantage: NITI Aayog’s Rajiv Kumar Punjab News, punjab groundwater issue, water issue in punjab, haryana groundwater issue, water issue in haryana, punjab water issue, haryana water issue, india news, Indian Express, Express Explained Water table dip and how Punjab must fight the looming crisis. (Representational)The NITI Aayog report claiming that 21 cities in India face groundwater extinction by 2020 has four cities from Punjab. UP Cabinet discusses NITI suggestions, merger of ministries, govt departments on the anvil The Indian Express explains how Punjab, which has only 1.57 per cent of the total land in the country, is the state with most cities (4 — Amritsar, Jalandhar, Ludhiana and Patiala) in the list after Rajasthan (5).What does the NITI Aayog report say?According to the scientists of Central Ground Water Board, this is a projection on the basis of the current GW (groundwater) extraction in these four cities of Punjab. They say that it does not mean that there would be no groundwater available in these cities after 2020, but the water availability in the aquifers available up to 200 to 300 meters would be finished and then more deep aquifers would be needed to meet the water need of these cities.What is the existing Gross Groundwater Draft (extraction of water) for domestic and industrial water supply in these four cities? Post Comment(s) Because the recharging is less, according to experts. In Punjab not even 20 per cent rain water is being used for recharging aquifers in the urban areas and the condition of these four big cities is worst where 65 per cent rain water goes into storm sewer and nearly five per cent goes back into the earth where earthy surfaces and green belts are available and remaining 30 per cent get accumulated on the concrete roads and streets where no kuccha (earthy) places are available and finally it either evaporates or take the form of slush till the time it gets dried, said scientists.What efforts are required to save upper aquifers?Scientists say that even if 50 per cent of rain water is sent into earth, then it would help save Punjab’s aquifers in urban areas. They said that Punjab’s groundwater level could be brought up by installing of water recharging system at individual houses starting from 200 sq yard and above. Every government, private building, schools, colleges should have this system. Also metered water supply with the water usage charges must be made compulsory to regulate water usage and cut down the wastage. There should be more green spaces for natural water recharging. Rain water must be harvested by collecting it in underground tanks in the areas where recharging is not possible. The stored water can be supplied after filtering for various purposes later on. In the fields where natural recharging takes place, there should be an arrangement on the sides of fields for sending excessive rain water into earth to bring the groundwater level up. Written by Anju Agnihotri Chaba | Updated: July 11, 2019 6:21:06 pmcenter_img Amritsar, Jalandhar, Ludhiana and Patiala cities having population up to 10 lakh and above have 45,747 hectare meter (ham) existing gross GW draft, including 10,014 ham for (Amritsar), 12,264 ham (Jalandhar), 16,330 ham (Ludhiana) and 7,139 ham (Patiala). By 2025, the provision needed will be total 61,313 ham water. The provision needed for respective cities by 2025 is 13,655 ham (Amritsar), 16,714 ham (Jalandhar), 21,176 ham (Ludhiana) and 9768 ham (Patiala).What is the groundwater exploitation rate of these cities?It is highly negative as already more water is being extracted against the recharge rate. In Amritsar, Jalandhar, Ludhiana and Patiala, the exploitation of water is 148 per cent, 239 per cent, 183 per cent and 217 per cent, respectively. These figures means that if 100 units of water are being recharged then we have not only extracted the recharged water but also the water earlier available in the underground aquifers. This figure revealed that even Jalandhar and Patiala have been over-exploiting more than double of its recharge rate.What is the average of GW extraction in the state?The state’s average is 166 per cent. Further, these four cities have higher extraction rate than the state average. The existing ground water draft in urban area is 1,21,772 hem out of which 37 per cent is supplied in these four cities only.Why exploitation of GW is more? Virat Kohli won’t have a say in choosing new coach Advertising Best Of Express After Masood Azhar blacklisting, more isolation for Pakistan Related News Advertisinglast_img read more

reMarkables Pricey PaperLike Tablet Ready to Ship

first_imgA Hard Sell Among reMarkable’s digital powers:10.3-inch monochrome digital paper display with 1872 x 1404 resolution (226 DPI) and multipoint capacitive touch;Marker pen with a high-friction tip and tilt detection — no battery or pairing required; WiFi connectivity; 8 GB of internal storage — the equivalent of 100,000 pages — and 512 MB of DDR3L RAM;Rechargeable battery (micro USB);1-GHz ARM A9 processor;Codex Linux-based operating system, optimized for e-paper;Support for PDF and ePub document formats; reMarkable app for instant syncing with all other devices; One-click file transfer; andOptional secure cloud backup service. Early Reactions The purchase price is US$599 for the reMarkable paper tablet, marker, marker tips and cable.More than 35,000 units already have been sold, according to the company.”With the right targeting, I can imagine a subset of e-reader users would really enjoy this product and could move up to this when deciding to replace their old Kindle or Kobo,” said Eric Smith, director, tablets and touchscreens, at Strategy Analytics.”The problem is, it’s already a limited pool of potential customers for a company with a limited marketing budget and distribution reach,” he told TechNewsWorld. “This is now just as expensive as a 10.5-inch iPad Pro with the Apple Pencil.”The pricing isn’t excessive, said Rob Enderle, principal analyst at the Enderle Group, because demand for e-paper displays isn’t as strong as for LCD displays.”You don’t get the massive economies of scale that LCD displays enjoy, particularly at this large size,” he told TechNewsWorld. “Lenovo’s Yoga Book and Yoga A12 are perfect examples of innovation in inking that really adds value to something many people already use,” said Strategy Analytics’ Smith.”Tablets equipped with another pane of glass for digitizing paper notes through EMR panels seems a more functional and less expensive innovation than reMarkable,” he suggested.The tablet “is going to be a really hard sell at such a high price point,” Smith said. “The price, low functionality and complicated workflow to move from connected device to ‘simplified’ reMarkable are big pain points.” “I do consider myself a ‘paper person.’ I’m someone who’s excited by the prospect of reading physical books and taking notes by hand,” wrote Avery Hartmans for Business Insider.”For that reason alone, I loved the experience of using reMarkable. It feels a lot like the early Kindles, but with … modern touches. Using it was a pleasant break from being constantly connected, and it was nice to have an excuse to doodle or write down to-do lists and notes,” she added.On the downside, it was “generally slow,” Hartmans pointed out. “For $600 I wanted the device to be quick and responsive, and it simply wasn’t.”Another problem was screen burn-in. Images remained faintly on the screen even after being erased, she noted.Although the reMarkable tablet didn’t quite meet her expectations, “I still think it’s an incredible product,” Hartmans wrote. However, “paying $600 for an E-ink tablet like this in 2017 still seems too steep to me.”The reMarkable tablet’s lack of additional functionalities — the ability to watch movies on it, play games or browse the Web — “is this device’s strongest feature,” Max Parker wrote for Trusted Reviews, because “it sets the [device] apart.”reMarkable is “a great tool for artists,” he said, noting that “the level of detail you can achieve is impressive.”However, he wasn’t impressed by the unremarkable design, and he would have preferred having the option to select a cloud service other than reMarkable’s.”You will be able to livestream from the reMarkable to a computer, however,” Parker pointed out, “which appears to make it an ideal tool for meetings and group working.”center_img Pricing and Demand reMarkable is about 7×10 inches and a mere quarter-inch thick. It weighs in at .77 pounds. It has no glass parts, and is virtually unbreakable, according to the company.It is powered in part by E Ink Carta technology. reMarkable on Monday will begin shipping what might best be described as an “untablet” — a device that is, essentially, an electronic piece of paper.The company is proud of its paper tablet’s simplicity, boasting that no other tablet has fewer functionalities.reMarkable users cannot install apps, watch videos or take photos. What they can do is read, write and sketch on a paper-like surface with a modern twist. Richard Adhikari has been an ECT News Network reporter since 2008. His areas of focus include cybersecurity, mobile technologies, CRM, databases, software development, mainframe and mid-range computing, and application development. He has written and edited for numerous publications, including Information Week and Computerworld. He is the author of two books on client/server technology. Email Richard.last_img read more

With Custom Skills Alexa Inches Closer to Being One of the Family

first_imgAmazon has touted Skill Blueprints as a way for people to build their skills, but it also could be an easy way for Amazon to add value to Alexa by having users create their own content.”Amazon Alexa Blueprints are not as much a new way of developingskills as they are easy-to-access training modules for buildingskills,” said Paul Teich, principal analyst at Tirias Research.”I see Alexa Blueprints as Amazon’s way of trying to boost the numberand quality of third-party apps available for its Alexa platform, andBlueprints should help Amazon increase the breadth and quality ofthird-party Alexa apps,” he told TechNewsWorld.”These companies hit each other over the head with more apps, so thisis an easy way to add it — even if it isn’t all that useful,” saidRoger Entner, principal analyst at Recon Analytics. Amazon on Thursday introduced Alexa Skill Blueprints, adding personalization capabilities to its smart speaker devices. The new tool provides pre-crafted templates for users to create customized experiences. Among the possibilities are answers to specific questions, or skills for particular users, such as houseguests.With Alexa Skill Blueprints, users can build into their devices experiences that are personalized for themselves, their friends and their families. The experiences they create will appear only on the devices registered to their Amazon account.The content can range from jokes and quips to important information for family members and caregivers. It also can be geared toward a student’s specific educational needs, for example.”You don’t need experience-building skills or coding to get started,”said Steve Rabuchin, vice president for Amazon Alexa.”My family created our own jokes skill in a matter of minutes, andit’s been a blast to interact with Alexa in a totally new and personalway,” he added.Alexa Skill Blueprints is now available for customers in the United States. Too Much Information App Builder This isn’t the first time a tech company has tried to turn user-generated content into a value add.”It reminds me of the old AutoContent Wizard in PowerPoint 2003 –which no one used,” said Roger Kay, principal analyst at EndpointTechnologies Associates.”The idea is to expand the pool of users capable of generating newapps — or “skills,” as Amazon calls them — and building Alexa’s skillslibrary is a top strategic priority for Amazon,” he told TechNewsWorld.However, this strategy may not impact the hardware platform, which iswhy other companies are going another route, added Tirias’ Teich.”Google is taking a different approach by selling its AIY kits through Maker outlets and now Target,” explained Teich.”That will help proliferate hardware products that use Google HomeAPIs,” he said, “as Target is already stocking both the Google Voice Kit AIY and Google Vision Kit AIY.” User-Generated Value Addcenter_img Because they are customizable, Alexa Skill Blueprints can be used in a variety of ways — but there are limits, as the tool relies on templates and filling in the blanks.At launch, Amazon unveiled templates in several key categories,including At Home, Fun & Games, Storyteller, and Learning & Knowledge.At Home includes options to provide quick access to information for houseguests, babysitters and pet sitters. Learning & Knowledge offers Alexa’s services as quizmaster in customized quizzes, keeper of facts, oreven flash card study companion.One entertainment template lets users enlist Alexa as a storyteller. Amazon has included options for adventure, fairy tale, sci-fi and fable-based stories.Fun & games templates include family jokes, multiple trivia options, compliments, and first letter. These allow the creation of highly customizable games for the whole family.”Amazon’s announcement will spark the fascination of all the ‘makers’in our midst,” said Josh Crandall, principal analyst at Netpop Research.”Imagine how cool somebody will look when they can show off theunique, imaginative skills that they programmed into their audio’friend,’ Alexa,” he told TechNewsWorld.”It doesn’t really matter how many people actually code skills. All itwill take to make this a PR win is a couple of YouTube videos ofcreative and funny skills that a few people add to their speakers,”Crandall added. Skills, Learning and Games One concern with technology such as Skill Blueprints is that personal information could be put at greater risk, as people might share too much with Alexa or other virtual assistants.”The downside to this is that people who want to do illicit thingscould now have access, writing skills for Alexa or accessing what hasbeen provided to the devices,” warned Recon Analytics’ Entner.”Everything can be hacked, and this opens the door,” he told TechNewsWorld. “If the content is easy enough for your dog sitter to access, then someone could hack into it. It is a big door that isbeing opened to your private information.” Peter Suciu has been an ECT News Network reporter since 2012. His areas of focus include cybersecurity, mobile phones, displays, streaming media, pay TV and autonomous vehicles. He has written and edited for numerous publications and websites, including Newsweek, Wired and FoxNews.com.Email Peter.last_img read more

Nvidias Turing Chip Opens Door to New Virtual Reality Realm

first_imgEngines of Mass Rendering What About Consumers? Worth the Expense Aimed at the US$250 billion visual effects industry, Turing combines two engines to make real-time ray tracing possible. Its RT Cores accelerate ray tracing, while its Tensor Cores are used for AI referencing.The RT Cores are dedicated ray-tracing processors that accelerate light and sound travel in 3D environments to up to 10 GigaRays a second. Turing accelerates real-time ray tracing operations by up to 25 times that of previous generation chips, Nvidia noted.What’s more, the architecture’s GPU nodes can be used for final-frame rendering for film at more than 30 times the speed of CPU nodes.The Tensor Cores are processors that accelerate deep learning training and inferencing. They’re capable of providing up to 500 trillion tensor operations per second.To help developers take advantage of Turing’s capabilities, Nvidia also introduced a new RTX development platform, which includes artificial intelligence, ray-tracing and simulation software development kits.In addition, it announced the Nvidia NGX software development kit, a deep-learning technology stack to help developers easily integrate accelerated, enhanced graphics, photo imaging and video processing into applications with pretrained networks. Nvidia’s initial Turing-based products are the Quadro RTX 8000 ($10,000), Quadro RTX 6000 ($6,300) and Quadro RTX 5000 ($2,300). They’re expected to be available in the fourth quarter.Despite the high price tags, they are in a class by themselves when it comes to performance and capabilities, suggested Anshel Sag, an analyst at Austin, Texas-based Moor Insights & Strategy, in a Forbes post.No other GPU can render complex ray-traced scenes in real time with just one GPU, which is something the RTX 8000 can do, he added.Even the best technology is irrelevant if no one uses it. Nvidia appears to have that base covered, though. With the Turing announcement it revealed pledges of support for the new architecture from developers of key graphics applications used by millions of designers, artists and scientists.Those applications include Adobe Dimension CC, Autodesk Arnold, Clarisse, DaVinci Resolve, Dassault Systemes Catia and Solidworks, Octane Render, ParaView, Redshift, Siemens NX, Unity and Unreal Engine.The companies’ support is a good indication that RTX will thrive, noted Sag. Holy Grail of Industry A wide variety of lighting effects that mimic real life can be rendered with Turing that in the past were just too resource-intensive to create in real time.”You’re moving from a painting to a photograph in terms of rendering quality,” said Daniel Wong, professor of electrical and computer engineering at the University of California, Riverside.”It will allow game developers to create more photorealistic games,” he told TechNewsWorld.”Now when you play a virtual reality game, you know you’re in a video game. With ray tracing, everything looks real because light is bouncing around as it does in real life,” Wong explained. “It will be possible in the future, with ray tracing, for you not to be able to tell the difference between the virtual reality world and the real world.” center_img “Turing is Nvidia’s most important innovation in computer graphics in more than a decade,” Huang said.”Hybrid rendering will change the industry, opening up amazing possibilities that enhance our lives with more beautiful designs, richer entertainment and more interactive experiences,” he predicted.”The arrival of real-time ray tracing is the Holy Grail of our industry,” added Huang.”This is a significant moment in the history of computer graphics,” said Jon Peddie, CEO of Jon Peddie Research in Tiburon, California. “Nvidia is delivering real-time ray tracing five years before we had thought possible.”All that power Turing promises won’t come cheaply, though.”Some of the cards will cost up to $10,000, but if you do graphics for a living, that has value for you,” observed Bob O’Donnell, chief analyst at Technalysis Research, a technology market research and consulting firm in Foster City, California. Nvidia on Monday announced a powerful new graphics architecture with the potential to blur the line between virtual and actual reality. Nvidia CEO Jensen Huang unveiled the new chips at the company’s SIGGRAPH 2018 event in Vancouver, Canada.The Turing architecture enables a new generation of hybrid rendering that can be used to create cinematic-quality interactive experiences, effects powered by neural networks, and fluid interactivity on highly complex models. Nvidia Turing Dieshot There is still an object missing object from the Turing picture.It’s likely that a part for consumer real-time ray-tracing is in the offing, according to Sag.However, access for consumers likely is years away, according to Brett L. Sappington, senior director of research at Parks Associates, a market research and consulting company in Addison, Texas.”This technology is primarily focused on professional graphics use rather than the consumer market,” he told TechNewsWorld.”It could have application in VR, particularly for business use cases. However, it is not likely to be a consumer product for several years,” Sappington said.”Nvidia has shown it’s very good over time at taking these high-end technologies and adapting them to the consumer market,” Technalysis’ O’Donnell told TechNewsWorld. “The challenge with this chip is that it is physically enormous in size, so it may be hard to shrink it down to something consumers can use.” John P. Mello Jr. has been an ECT News Network reportersince 2003. His areas of focus include cybersecurity, IT issues, privacy, e-commerce, social media, artificial intelligence, big data and consumer electronics. He has written and edited for numerous publications, including the Boston Business Journal, theBoston Phoenix, Megapixel.Net and GovernmentSecurity News. Email John.last_img read more

TGFbeta signaling pathway in uterine cells protects against cancer

first_img Source:https://www.bcm.edu/ Reviewed by James Ives, M.Psych. (Editor)Jan 16 2019Two new mouse models of uterine cancer shed light on how this disease – the most common gynecological cancer in the U.S. – happens. Led by researchers at Baylor College of Medicine, the team of scientists found that the Transforming Growth Factor beta (TGF-beta) signaling pathway in uterine cells protects against the disease by suppressing the overgrowth and transformation into cancer cells of the endometrium, the membrane lining the inside of the uterus.The findings, which are published in two papers in the Proceedings of the National Academy of Sciences (PNAS) today, suggest potential new therapeutic strategies that could be beneficial to patients in the future.”The TGF-beta signaling pathway regulates the development of many types of cancer, but it was not clear whether it also played a role in uterine cancer development,” said corresponding author Dr. Martin M. Matzuk, director of the Center for Drug Discovery, Stuart A. Wallace Chair, Robert L. Moody, Sr. Chair and professor of pathology & immunology at Baylor College of Medicine.To explore the role the TGF-beta pathway plays in uterine cancer, the Matzuk lab developed two new mouse models of the disease. Each mouse model tested the effect of lacking specific proteins participating in the TGF-beta pathway; one model was studied in the absence of the protein TGF-beta receptor ALK5 and the other model tested the inactivation of both Smad2 and Smad3, proteins downstream of the receptor.”The mice lacking ALK5 developed metastatic endometrial tumors with cervical and vaginal masses. The tumors were estrogen-dependent, meaning they required estrogen to grow. When the ovaries – the natural source of estrogen – were removed, both the tumors and metastases to the lungs regressed,” Monsivais said. “These and other results indicate that it is important to maintain TGF-beta signaling via ALK5 to sustain the health and normal function of the uterus.” This study is in this PNAS article.Related StoriesResearchers identify potential drug target for multiple cancer typesUsing machine learning algorithm to accurately diagnose breast cancerResearchers use AI to develop early gastric cancer endoscopic diagnosis systemThe second mouse model was developed by Dr. Maya Kriseman, reproductive endocrinology and infertility fellow in the Department of Obstetrics and Gynecology at Baylor College of Medicine, and her colleagues. In this case, the researchers genetically modified mice to lack two other proteins, Smad2 and Smad3, which transmit the signal from the TGF-beta receptors to the nucleus. Then, they assessed the effect of lacking these proteins in tumor development.”I found that disrupting these particular proteins, Smad2 and Smad3 in mice, caused a very aggressive hyperplasia or overgrowth of the endometrium that rapidly developed into cancer and death,” Kriseman said. “These effects were dependent on estrogen, which also is a characteristic of the most common type of uterine cancer in humans. These and other findings give us a better idea as to why these mice develop aggressive uterine tumors and escape normal endometrial regulation.” This study can be found in this PNAS paper.”Taken together, the findings of Monsivais and Kriseman strongly suggest that the TGF-beta pathway is a tumor-suppressor mechanism in the uterus,” said Matzuk, who also is a member of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine. “We anticipate that the new mouse models we have generated can be further used to uncover other processes that can lead to uterine cancer.””Dissecting the complex cascade of biological events that are necessary for protecting the uterus from cancer and for sustaining normal fertility is critical. By revealing that the TGF-beta pathway plays a protective role against uterine cancer, this work has significantly advanced our understanding of the disease and opened novel avenues for future therapeutic strategies,” said Dr. William E. Gibbons, professor of obstetrics and gynecology and director of reproductive endocrinology and infertility at Baylor College of Medicine.last_img read more

Light physical activity may lower risk of cardiovascular disease in older women

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Mar 15 2019Light physical activity such as gardening, strolling through a park, and folding clothes might be enough to significantly lower the risk of cardiovascular disease among women 63 and older, a new study has found. This kind of activity, researchers said, appears to reduce the risk of cardiovascular disease events such as stroke or heart failure by up to 22 percent, and the risk of heart attack or coronary death, by as much as 42 percent.The results of the study, which was funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, appear today in the journal JAMA Network Open.”When we tell people to move with heart, we mean it, and the supporting evidence keeps growing,” said David Goff, M.D., Ph.D., director of the Division of Cardiovascular Sciences at NHLBI. “This study suggests that for older women, any and all movement counts towards better cardiovascular health.” Goff added that the findings are consistent with the federal government’s most recent physical activity guidelines, which encourage replacing sedentary behavior with light physical activity as much as possible.In the five-year prospective study, researchers followed more than 5,800 women ages 63 to 97 to find out if higher amounts of light physical activity were associated with reduced risks of coronary heart disease or cardiovascular disease.Across all racial and ethnic groups, the link was clear, said study author Andrea LaCroix, Ph.D., chair of the Division of Epidemiology and director of the Women’s Health Center of Excellence at the University of California, San Diego.”The higher the amount of activity, the lower the risk,” she said. “And the risk reduction showed regardless of the women’s overall health status, functional ability or even age. In other words, the association with light physical activity was apparent regardless of these other factors.”Heart disease is the leading cause of death among American women, and older women suffer profoundly: nearly 68 percent of those between 60 and 79 have it, as do older Americans overall. Of the estimated 85.6 million adults with at least one type of cardiovascular disease, more than half are age 60 or older.Related StoriesWeightlifting is better for the heart than cardioTeam approach to care increases likelihood of surviving refractory cardiogenic shockHeart disease is still the number 1 killer in Australia, according to latest figuresThe current study involved a racially and ethnically diverse group of 5,861 women who were enrolled between 2012 and 2014. None had a history of myocardial infarction or stroke. The women were part of the NHLBI-funded Objective Physical Activity and Cardiovascular Health (OPACH), a sub-cohort of the Women’s Health Initiative.Participants wore hip-mounted accelerometers, a device like a fitness tracker, that measured their movement 24 hours a day for seven consecutive days. The accelerometers were also calibrated by age to distinguish between light, and moderate-to-vigorous physical activity–a monitoring detail considered a major strength of the study. The researchers then followed the participants for almost five years, tracking cardiovascular disease events such as heart attacks and strokes.”To our knowledge, this is the first study to investigate light physical activity measured by accelerometer in relation to fatal and non-fatal coronary heart disease in older women,” said LaCroix, who led the OPACH study.Previous studies have largely relied on self-reporting questionnaires, but most people, the researchers said, do not think of folding clothes or walking to the mailbox as physical activity of any kind.”Those questionnaires do not capture the low intensity movements accrued in activities of daily living,” LaCroix said. Even in her own OPACH findings, she noted, “there was no correlation between the amount of self-reported light physical activity and the amount we measured with the accelerometers. Without accurate reporting, we run the risk of discounting low intensity activity associated with important heart health benefits,” she said.Researchers need to conduct large randomized trials to determine if particular interventions might increase light physical activity in older women, and what effect that would have on cardiovascular disease rates. But the OPACH authors said they encourage this group to increase their light physical activity immediately.Source: https://www.nih.gov/news-events/news-releases/light-physical-activity-linked-lower-risk-heart-disease-older-womenlast_img read more

Study highlights the need for psychiatric care to be integrated into cancer

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 18 2019Patients with prostate, bladder or kidney cancers are at greater risk of dying if they have had psychiatric care prior to the cancer treatment. In addition, patients with these cancers show greater suicide risk than the general population, even once the data is corrected for previous psychiatric care. These are the main findings of a new study presented at the European Association of Urology congress in Barcelona. They highlight the need for psychiatric care to be integrated into cancer treatment.There is emerging evidence that cancer survival rate is influenced by the mental health state of the patient. This work is the first which relates urological cancer survival to previous (within 5 years) use of psychiatric services, giving scientists an indication of the mental health state of patient before the cancer diagnosis. This is part of a larger study looking at the effect of mental health on cancer survival.What did they do?A US/Canadian team led by Assistant Professor Zachary Klaassen (Georgia Cancer Centre, Augusta, Georgia) looked at the mental health records of 191,068 urology cancer patients from Ontario in Canada (where Professor Klaassen was on temporary assignment). These patients had either suffered from prostate, bladder, or kidney cancer. They then assigned each patient a score based on whether they had used psychiatric services within the previous 5 years. 57.1% had not used these services whereas the remaining patients had received outpatient treatment (41.6%), emergency department treatment (0.84%) or hospital admission (0.40%). The patients were matched to 528,387 control patients, i.e. patients who had not suffered any cancers.What did they find?The researchers found that patients previously treated for mental health conditions had a greater risk of dying of their cancer than those who had not been treated, with the mortality risk increasing in line with the intensity of the prior mental health treatment. For example, the odds of cancer mortality were 1.78 times greater in patients who had been hospitalised for mental health problems, when compared with controls (Hazard Ratio, 1.78).Zachary Klaassen said,”This is the first large, population-level study to show that patients with previous mental health problems are at greater risk of dying of their cancer compared to patients with no mental health history. We believe that there will be several factors behind this, but we need more studies to understand the causes”. A second analysis looked at suicide rates following diagnosis and treatment with prostate, bladder, or kidney cancer. In common with other findings, the researchers found that suicide rates increased after cancer diagnosis. Professor Klaassen commented:Related StoriesOnline training program helps managers to support employees’ mental health needsInternational study aims to more accurately describe mental health disordersHospitals’ decision to transfer kids with mental health emergencies is based on insurance type”This is the first population-level suicide study where we have been able to adjust for previous psychiatric history. We found that whereas the overall risk of suicide increased by around 16% (HR=1.16) for patients who had been diagnosed with these cancers, it went up by around 39% (HR=1.39) in patients who had no previous history of mental health treatment. This shows the significant toll that cancer diagnosis has on the mental health of patients.In general, we can say that patients with genitourinary malignancies who have utilized psychiatric services in the five years leading up to their cancer diagnosis are at increased risk of dying of their cancer compared to patients with the same cancer who have not sought psychiatric help. Furthermore, these patients are at greater risk of suicide. The exact reason for this relationship is unknown, however it highlights the importance of identifying at-risk patients and having a multi-disciplinary approach (including psycho-oncology) to managing these patients”.”There are more than 20 population-level studies suggesting that cancer patients are at increased risk of suicide compared to the general population. This is the first study to account for pre-diagnosis psychiatric status, and it confirms that a cancer diagnosis in itself is a driving factor for suicidal risk. Considering that several studies have suggested that bladder cancer patients are amongst the highest-risk patients, at the Georgia Cancer Center we are working towards including prior psychiatric data on these patients to help us understand if early psychiatric assistance may help in the overall outcome. We think that this needs to be generally considered for these patients.”Commenting, Professor Francesco Montorsi (Milano), European Association of Urology’s Adjunct Secretary General for Science said:”This large study shows that pre-existing mental state can have a significant influence on cancer outcomes. In addition, it shows that just the diagnosis of cancer can have a bearing on whether or not the patient attempts suicide. The clinical community has a duty to treat the whole patient, not just the cancer, so we need to take note of these findings, and where possible to include appropriate precautions to take account of a patient’s mental health history” Source: https://uroweb.org/last_img read more

Auburn study explains link between habitat loss and global emergence of infectious

first_imgThe field of disease ecology is heavily based on a hypothesis known as the dilution effect, which was released at the turn of this century. It is essentially the idea that biodiversity conservation can protect humans from emerging infectious diseases. Zohdy said the dilution effect highlights the critical role that wildlife conservation can play in protecting human health and has transformed the understanding of zoonotic infectious diseases.Related StoriesVirus killing protein could be the real antiviral hero finds studyAntibiotic combination effective against drug-resistant PseudomonasTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTHowever, until now, even after a wealth of research in the past few decades has explored that hypothesis and found associations between the loss of biodiversity and EIDs, there has been no explanation for where the microbes that cause EIDs come from and how they get to humans.”Through our hypothesis, we propose that as humans alter the landscape through habitat loss, forest fragments act as islands, and the wildlife hosts and disease-causing microbes that live within them undergo rapid diversification,” Zohdy said. “Across a fragmented landscape we would then see an increase in diversity of disease-causing microbes, increasing the probability that any one of these microbes may spill over into human populations, leading to outbreaks.”Oaks said he is encouraged that the research will impact the way these problems are perceived.”Our paper introduces an evolutionary mechanism to explain the association between habitat fragmentation and disease spillover into human populations, which we hope will complement the ecological perspectives on this global health challenge,” he said.School of Forestry and Wildlife Sciences Dean Janaki Alavalapati said the paper’s findings are compelling.”Dr. Zohdy and her fellow researchers provide noteworthy insights in the field of emerging infectious diseases and the driving forces behind them,” Alavalapati said. “Their findings could result in a significant shift in the way the origins of these diseases are perceived.” Source:Auburn UniversityJournal reference:Zohdy, S. et al. (2019) The Coevolution Effect as a Driver of Spillover. Trends in Parasitology. doi.org/10.1016/j.pt.2019.03.010. We provide a testable hypothesis that we hope other researchers will try to test with their data, as we will be doing. Whether or not these studies fully support this new hypothesis, we anticipate it will provide a new perspective that other researchers in this field can use and build on, to ultimately push this field forward to understand disease spillover and prevent it.”Tonia Schwartz, assistant professor, Auburn University Reviewed by James Ives, M.Psych. (Editor)Jun 24 2019Auburn University researchers have published a new hypothesis that could provide the foundation for new scientific studies looking into the association of habitat loss and the global emergence of infectious diseases.They present their research in the paper, “The Coevolution Effect as a Driver of Spillover,” in the latest issue of the scientific journal, Trends in Parasitology.”We provide a new perspective about how habitat loss can facilitate the emergence of infectious diseases in humans,” said Sarah Zohdy, assistant professor in the School of Forestry and Wildlife Sciences and the College of Veterinary Medicine, who coauthored the study with Tonia Schwartz and Jamie Oaks, assistant professors in the Department of Biological Sciences in the College of Sciences and Mathematics.Globally, scientists believe habitat loss is associated with emerging infectious diseases, or EIDs, spreading from wildlife to humans, such as Ebola, West Nile virus, SARS, Marburg virus and others. The Auburn team developed a new hypothesis, the coevolution effect, which is rooted in ecology and evolutionary biology, to explain the underlying mechanisms that drive this association.Schwartz said the team integrated ideas from multiple aspects of biology, including disease ecology, evolutionary biology and landscape genetics, to develop the new hypothesis on why diseases are more likely to spill over from wildlife to humans in deforested habitats.last_img read more

Research opens door to better treatment for common cause of diarrhea

first_imgThe findings are published online June 20 in Cell Host & Microbe.In wealthy countries, Cryptosporidium is notorious for causing water-borne outbreaks of diarrhea. The parasite goes through a complex life cycle, including a stage in which it is called an oocyst and becomes hardy, spore-like and hard to kill with chlorine, bleach or other routine sanitation measures. In 1993, 400,000 people in the Milwaukee area developed diarrhea, stomach cramps and fever after a malfunctioning water purification plant allowedCryptosporidium into the city’s water supply. Every year, dozens of smaller outbreaks are reported in the U.S., many associated with swimming pools and water playgrounds.Diarrhea caused by the parasite can last for weeks. While this is miserable for otherwise healthy people, it can be life-threatening for undernourished children and people with compromised immune systems.Until now, researchers who wanted to study the parasite had to obtain oocysts from infected calves – Cryptosporidium infection is a serious problem in commercial cattle farming – and grow the parasites in human or mouse cell lines. The parasite inevitably would die after a few days without going through a complete life cycle, so the researchers would have to obtain more oocysts from cattle to do more experiments.Sibley, along with co-first authors Georgia Wilke, PhD, who is a student in the Medical Scientist Training Program, and postdoctoral researcher Lisa Funkhouser-Jones, PhD, suspected that the problem lay in the cell lines traditionally used to grow the parasite. Derived from cancer cells, these cell lines were very different from the normal, healthy intestine that is the parasites’ usual home.Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Why Mattresses Could be a Health Threat to Sleeping ChildrenTo create a more natural environment, the researchers collaborated with Thaddeus S. Stappenbeck, MD, PhD, the Conan Professor of Laboratory and Genomic Medicine and a co-author on the paper. Stappenbeck and colleagues cultured intestinal stem cells to become “mini-guts” in a dish – complete with all the cell types and structural complexity of a real intestine.When the researchers added oocysts to the mini-guts, the parasites thrived. They emerged from the oocysts and went through their full life cycle to produce more oocysts. For the first time, every stage of the parasite’s complicated life cycle could be studied in the lab. The researchers also showed that they could edit the parasite’s genes with CRISPR/Cas9 and perform genetic crosses, making these powerful tools for studying biology more accessible than before.”We put the parasite in this environment that is much more natural, and it’s happy and it grows and develops and goes through the entire life cycle,” Sibley said. “This opens up possibilities that were closed for a long time. There is only one FDA-approved drug, and it doesn’t work in young children. There are potential drug candidates, but we couldn’t screen them before because the parasites would just die anyway. How can you tell if the drug is killing the parasites if they are already dying? Now we can start screening drugs and also start asking questions about what makes this parasite dangerous.”The technique applies only to C. parvum, one of the two most common Cryptosporidium species that cause diarrhea in people. Its cousin C. hominis is even more difficult to grow in the lab. The two are closely related, but while C. parvum can infect young mammals of many species, C. hominis only infects people.”There are only a few dozen genes that are different between parvum and hominis but somehow that’s enough to make hominis very finicky,” Sibley said. “It won’t grow in mice or in calves or, so far, in mini-guts grown from mouse stem cells. Developing systems to work with hominis is an important goal of my lab.”The technique, while potentially powerful, will not immediately translate into better treatment or prevention for diarrhea, Sibley cautioned.”These things take time,” Sibley said. “There’s a lot of basic research that still needs to be done. But this system provides an important path forward. We can now use genetic approaches to study the role of individual genes and thereby identify important targets for improved therapies.” Source:Washington University School of Medicine in St. Louis This parasite was described over 100 years ago, and scientists have never been able to reliably grow it in the lab, which has hampered our ability to understand the parasite and develop treatments for it. We now have a way to cultivate it, propagate it, modify its genes and start figuring out how it causes disease in children. This is a first step toward screening potential drugs and finding new drugs or vaccine targets.”Senior author L. David Sibley, PhD, the Alan A. and Edith L. Wolff Distinguished Professor of Molecular Microbiology Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 20 2019One of the most common causes of diarrhea worldwide – accounting for millions of cases and tens of thousands of deaths, mostly of small children – is the parasite Cryptosporidium. Doctors can treat children with Cryptosporidium for dehydration, but unlike many other causes of diarrhea, there are no drugs to kill the parasite or vaccines to prevent infection.Now, researchers at Washington University School of Medicine in St. Louis have figured out how to grow the most common type of Cryptosporidium in the lab, a technological advance that will accelerate efforts to treat the deadly infection.last_img read more

Google selfdriving van involved in crash in Arizona driver injured Update

Explore further Citation: Google self-driving van involved in crash in Arizona, driver injured (Update) (2018, May 5) retrieved 18 July 2019 from https://phys.org/news/2018-05-waymo-self-driving-car-collision-arizona.html Photos taken at the scene show significant damage to the driver’s side of the Waymo van and the front of a silver Honda sedan, with pieces of both vehicles scattered across the roadway.The Honda was driving eastbound in Chandler, Ariz. when it swerved to avoid striking a vehicle that was driving northbound. As the sedan swerved, it struck the Waymo van, which was traveling at low speeds in autonomous, or self-driving, mode, Detective Seth Tyler of the Chandler police said.There was an occupant in the driver’s seat of the Waymo vehicle who suffered minor injuries, Tyler added.Both the Waymo vehicle and Honda sedan were damaged and had to be towed.Chandler is a suburb to the southeast of Phoenix where Waymo has been testing its self-driving vehicles. Waymo is autonomous vehicle subsidiary of Alphabet, the parent company of Google.Accidents involving self-driving cars in Arizona have raised questions about whether the tech is ready for testing with the public. There have been at least three accidents involving Waymo autonomous vehicles in Chandler in the past two years, involving human drivers who ran into Waymo cars.On March 18 an Uber self-driving car hit and killed a woman who was walking a bike across a busy street outside any crosswalk into traffic.Arizona Gov. Doug Ducey ordered testing of Uber cars be suspended soon after the fatality, but not all self-driving operations were stopped. Uber suspended self-driving operations elsewhere after the accident while it investigated the crash.Last month, Waymo CEO John Krafcik said he had confidence that the company’s technology was robust enough to handle “situations like that one.”Waymo did not immediately respond to request for comment Friday.Marsh reporting from Phoenix, Ariz. Weise reporting from San Francisco. A self-driving van that was part of Google’s tests in Arizona was involved in an accident Friday when a car being driven by a human swerved to avoid another human-driven car and crashed into it. CEO says Waymo dedicated to safe self-driving technology ©2018 USA Today Distributed by Tribune Content Agency, LLC. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Airbus warns could leave UK if no Brexit deal

first_img Explore further Airbus employs nearly 15,000 people at more than 25 sites in Britain, where it manufactures the wings of its aircraft Airbus says delays and disruptions to its production could be “catastrophic” Aviation giant Airbus has warned it could pull out of Britain if it leaves the European Union without a deal, upping the pressure Friday on Prime Minister Theresa May to make progress in negotiations with Brussels. Airbus deal with Canada’s Bombardier set for take-off This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Airbus warns could leave UK if no Brexit deal (2018, June 22) retrieved 18 July 2019 from https://phys.org/news/2018-06-airbus-britain-brexit.html Transition ‘too short’The government has agreed a post-Brexit transition period that will last until December 2020, to allow time for a new economic partnership to be struck with the EU.But Airbus said this was “too short” for a new agreement to be made and “too short for Airbus to implement the required changes with its extensive supply chain”.”In this scenario, Airbus would carefully monitor any new investments in the UK and refrain from extending the UK suppliers/partners base,” it said.Williams admitted that “in any scenario, Brexit has severe negative consequences for the UK aerospace industry and Airbus in particular”.He called for more clarity on the situation, adding: “We have sought to highlight our concerns over the past 12 months, without success.”The government spokesman said it was “working closely with companies to understand their concerns”.”Alongside industry (it) will invest almost £4 billion by 2026 to ensure the UK remains a world leader in civil aerospace,” he said.Parliament finally approved the government’s flagship EU (Withdrawal) Bill this week, ensuring that Britain can now legally leave the bloc, deal or no deal. “We have repeatedly warned that the UK cannot take the huge economic risk of cutting ourselves adrift from the single market and the customs union,” a spokesman said.A string of airlines, banks and other corporate household names have already activated their contingency plans to move jobs or restructure because of Brexit. The European group, which directly employs nearly 15,000 people in Britain, warned that crashing out of the bloc would be “catastrophic” and force it to consider its investments.”Put simply, a ‘no deal’ scenario directly threatens Airbus’ future in the UK,” said chief operating officer Tom Williams, almost two years since Britain voted to leave the EU.May’s government insists it must hold out the possibility of walking away as a negotiating tactic, but says it expects to get a deal before it exits the bloc on March 29, 2019.”We have made significant progress towards agreeing a deep and special partnership with the EU to ensure trade remains as free and frictionless as possible, including in the aerospace sector,” a spokeswoman said.However, talks are stalled on the issue of the Irish border and Britain’s indecision over the deal it wants.EU leaders, who will meet May at a Brussels summit next week, have warned that time is running out.”While Airbus understands that the political process must go on, as a responsible business we require immediate details on the pragmatic steps that should be taken to operate competitively,” Williams said. No deal ‘catastrophic’In a Brexit risk assessment, Airbus said leaving the EU’s single market and customs union immediately with no agreed transition deal “would lead to severe disruption and interruption of UK production”.Delays and disruptions to its production could cost it up to one billion euros ($1.2 billion) a week in lost turnover and would be “catastrophic”.”This scenario would force Airbus to reconsider its investments in the UK, and its long-term footprint in the country,” the report published late Thursday said.Airbus builds wings and landing gear for commercial aircraft at 25 centres in Britain and also has a space technology centre.It directly employs nearly 15,000 people and also supports more than 100,000 further jobs in the supply chain. The prospect of losing so many jobs has sparked widespread alarm.In Wales, where Airbus supports around 11,700 jobs, the devolved government run by the UK opposition Labour party said its report was “extremely worrying”. © 2018 AFP Airbus says the post-Brexit transition period is “too short”last_img read more

Chips are down for online gamblers as US moves toward new ban

first_img The Justice Department earlier this month released a legal opinion stating that any form of online betting, not just sports betting, would be a violation of the federal Wire Act.That could shut down online poker, casino and lottery offerings launched in a handful of states since a 2011 decision by the Obama administration to refrain from prosecuting any online betting that is not sports-related.”It could have a signficant impact but it will depend on whether the DoJ strictly enforces its new interpretation,” said Jennifer Roberts, associate director of the International Center for Gaming Regulation at the University of Nevada-Las Vegas.Roberts said a very strict interpretation could shut down fantasy sports leagues that have grown in recent years and potentially any online wagering even if confined to a single state where betting is legal.”Even if the betting takes place in a jurisdiction where it’s legal, if the communication is routed into another state that could trigger the Wire Act,” Roberts told AFP.The Wire Act is a 1961 law that bars the use of telecommunications for gambling as part of an effort to crack down on organized crime. Since the 2011 interpretation, various forms of online gambling have begun in Nevada, Delaware, New Jersey and Pennsylvania, with a handful of other states considering legalization.While there is no comprehensive breakdown of US online gambling revenues, total wagers were up near 22 percent to $298 million last year in New Jersey, which has the largest internet segment.90-day windowIn the latest opinion, the Justice Department stopped short of indicating how far it would go in enforcement. But in a January 15 memo, deputy attorney general Rod Rosenstein said prosecutions could begin after 90 days.”A 90-day window will give businesses that relied on the 2011 … opinion time to bring their operations into compliance with federal law,” Rosenstein said. “This is an internal exercise of prosecutorial discretion; it is not a safe harbor for violations of the Wire Act.” Explore further © 2019 AFP US authorities have begun an effort to ban all forms of internet gambling, reversing course from a 2011 decision and imperiling a burgeoning online wagering sector in several American states. For many years, online gambling was opposed by the US casino industry, but recently some traditional gaming operators have joined the move to internet wagering.Casino operators including Caesars Entertainment and Golden Nugget now take online bets where legally allowed, making it as easy to wager as tapping on a smartphone.Betting on the futureThe new Justice Department policy follows a lengthy lobbying campaign by the Coalition to Stop Internet Gambling, a group backed by Las Vegas casino owner Sheldon Adelson, a prominent backer of President Donald Trump.The group applauded the new policy guidance, repeating its concerns that online wagering could get consumers, including minors, hooked on gambling.”Countries around the world offer a perilous preview of where our nation was headed absent today’s action from the federal government,” the coalition said in a statement.”In the UK, which is the epicenter of the epidemic… over half of 16-year-olds have gambling apps on their smartphones. Further, the iGaming industry obtains more than half of its profit from problem gamblers.”Senator Lindsey Graham, head of the Judiciary Committee, also welcomed the decision.”Restoring the original interpretation of the Wire Act takes great strides to protect children and society’s most vulnerable,” Graham said in a statement.But Michelle Minton, a senior fellow at the Competitive Enterprise Institute, said the move would just force gamblers to go to illegal sites with fewer scruples.”Prohibition has never worked,” Minton said. “It just turns law-abiding citizens into lawbreakers and reduces the level of trust in government.”Minton said the new legal opinion is likely to create further confusion, and may dissuade states from authorizing new internet gambling operations. It is likely to lead to spate of legal challenges over online betting in various state, she added.”They may choose to not prosecute, knowing it will never hold up in a court of law, and as a result the uncertainty in the law would persist,” she said. “My bet is that there won’t be prosecutions.”center_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. US gambling operators have 90 days to comply with new rules Citation: Chips are down for online gamblers as US moves toward new ban (2019, January 20) retrieved 17 July 2019 from https://phys.org/news/2019-01-chips-online-gamblers.htmllast_img read more

Instagram moves into ecommerce with shopping button

first_img Facebook-owned Instagram getting into shopping This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Facebook-owned Instagram on Tuesday made a move into potentially lucrative e-commerce by adding an option to buy products shown off in posts by selected brands. A new “checkout” button for instant purchasing launched in a beta version of the app in the US with a limited number of businesses, according to the popular image-centric messaging service.”We’re introducing Checkout on Instagram,” the Silicon Valley based division of Facebook said in an online post.”When you find a product you love, you can now buy it without leaving the app.”Tapping the checkout button will allow shoppers to select options such as size or color and then pay for items without leaving the Instagram app.Previously, people inspired to buy products featured in Instagram posts had to follow links to outside online shopping sites.Information entered for an initial purchase will be stored for future use, according to Instagram.It remained to be seen how people would feel trusting information such as credit card details to a service owned by Facebook, which has been hit with waves of criticism for its handling of personal data.Brands taking part in the checkout feature included Adidas, Burberry, Dior, H&M, Nike, Oscar de la Renta, Prada, and glasses retailer Warby Parker.Facebook makes the bulk of its money from digital advertising but has dabbled with e-commerce in the past. It has pitched its Messenger service as a communication platform for shops or brands to connect with customers. Citation: Instagram moves into e-commerce with shopping button (2019, March 20) retrieved 17 July 2019 from https://phys.org/news/2019-03-instagram-e-commerce-button.htmlcenter_img Explore further Tapping the new “checkout” button will allow shoppers to select options such as size or color and then pay for items without leaving the Instagram app © 2019 AFPlast_img read more

Dozens of Pilot Whales Washed Up on Georgia Beach and Beachgoers Came

first_img Striking Shots: Winning Photos Reveal Amazing Life Underwater Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GameIf You’re Over 40 And Own A Computer, This Game Is A Must-Have!Vikings: Free Online GameUndoDr. Marty Nature's Feast Freeze-Dried RAW Cat Food3 Signs Something’s Wrong Inside Your Cat’s BodyDr. Marty Nature’s Feast Freeze-Dried RAW Cat FoodUndoClassmatesSearch For Any High School Yearbook, It’s Free.ClassmatesUndoMarie Claire | HanacureMeet The Beauty Equivalent To TIME’s Person Of The Year AwardMarie Claire | HanacureUndoGundry MD SupplementsTop Cardiologist: This One Thing Will Properly Flush Out Your BowelsGundry MD SupplementsUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndo Deep Divers: A Gallery of Dolphins After dozens of pilot whales beached themselves on St. Simons Island, Georgia, yesterday evening (July 16), concerned beachgoers, lifeguards and wildlife officials sprang into action, doing their best to maneuver the whales back into the water. “While stranding is a known natural occurrence, the only thing we can do is to continue pushing them out to sea,” Clay George, a wildlife biologist with Georgia’s Department of Natural Resources (DNR), said in a statement. Dixie McCoy, a beach visitor and resident of St. Simons Island, posted a heartbreaking video on Facebook that shows the whales struggling to get back in the water. “How the heck did so many get washed up over here?” someone asked.Advertisement “All these whales have been washed up to shore and there’s already been one whale that’s been attacked by a shark,” McCoy said in the video. “It is so sad.” McCoy estimated there were around 40 animals on the beach, but the local news agency WJCL reported there were more than 50 beached whales. People of all ages put forth a valiant effort, working together to push most of the distressed marine mammals back out to sea. “I tell you what, Glenn County came together on this one,” McCoy said. But despite the beachgoers’ remarkable achievement, some of the whales returned to the beach. At least two of the whales died and were taken to be necropsied, Georgia DNR reported. The remaining whales were last seen swimming close to shore, and wildlife officials hope the whales continue moving out to sea. More Than 140 Pilot Whales Found Dead on Remote New Zealand BeachTwo groups of more than 140 long finned pilot whales (Globicephala melas) mysteriously stranded on a remote beach in New Zealand over the weekend, and none of the poor creatures survived. Credit: New Zealand Department of ConservationVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65961-pilot-whale-stranding-georgia.html?jwsource=cl已复制直播00:0000:2400:24Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball01:08Why Do French Fries Taste So Bad When They’re Cold?02:31Surgical Robotics00:29Video – Giggly Robot关闭  Why did they strand? Pilot whales are one of the largest members of the dolphin family, second only to the killer whale in size, according to the American Cetacean Society (ACS). The whales that stranded in Georgia were likely short-finned pilot whales (Globicephala macrorhynchus). Short-finned and long-finned pilot whales (Globicephala melas) look almost identical when seen in the wild, but the two species differ in fin length, tooth count and skull shape. The short-finned are found in subtropical and tropical areas, while the long-finned are found in the higher latitudes of both hemispheres, according to the ACS. Both species of pilot whales are very social and travel in groups of 20 to 90 individuals, and it’s not unusual for the large groups to strand together. The largest documented stranding of pilot whales happened in 1918, when an estimated 1,000 whales beached themselves at the Chatham Islands, 497 miles (800 km) east of the South Island of New Zealand, according to the country’s Department of Conservation. But why the whales exhibit this deadly behavior remains a mystery to scientists. The most agreed-upon hypothesis is that the whales’ echolocation isn’t as effective in shallow, near-shore waters as it is near the steep underwater cliffs at the edge of the continental shelf, according to New Zealand’s Department of Conservation. Like other cetaceans, pilot whales use echolocation to find their prey — primarily squid. It’s possible that when the whales follow prey closer to shore, the whales become disoriented and are unable to find their way back to sea before beaching themselves. It’s also possible that the whales’ social tendencies mean that when one whale washes ashore, others follow to help out, only to get stuck themselves. It could also be a combination of factors that causes the animals to strand, but those reasons remain unknown. Short-finned pilot whales are considered a species of least concern, according to the International Union for the Conservation of Nature and Natural Resources (IUCN), and the ACS estimates there are about 200,000 short-finned pilot whales worldwide. Whale Album: Giants of the Deeplast_img read more

Amazon Prime Day Best Health Fitness Deals

first_imgPrime Day, Amazon’s day of deals, is here. To help you make the most of it, we’ve rounded up some of Amazon’s best deals on health and fitness products, both practical and quirky.  Folding Pedal Exerciser This pedal exerciser is a great way to exercise and improve blood circulation while sitting at a desk or on a couch, and it folds up for easy storage and carrying.These Sharks Were Too Busy to Notice a Bigger Predator Watching ThemThe unexpected twist at the end of this feeding frenzy delighted scientists.Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Headbutting Tiny Worms Are Really, Really Loud00:35关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/63073-amazon-prime-day-best-health-fitness-deals.html?jwsource=cl已复制直播00:0002:2802:28  Prime Day price: $25.49, a savings of 25% for Prime members Buy Folding Pedal Exerciser on Amazon.com Portable Air Purifier The Airdog FitAir Portable Air Purifier with HEPA Filter will continuously clean the air in a 25-square-foot (2-square-meter) area, filtering pollen, smoke, and other particles. The filter typically lasts for 1 to 2 months in a polluted environment and for 2 to 4 months when pollution is low. Prime Day price: $79.20, a savings of 20% for Prime members Buy Portable Air Purifier on Amazon.com Dog Frisbee and Rope Toy Exercise and have fun with your dog with this ring frisbee and rope toy set. Both items are made of durable, nontoxic rubber and the rope is heavy nylon. Prime Day price: $24.79, a savings of 20% for Prime members Buy Dog Frisbee and Rope Toy on Amazon.com White Noise Sound Machine Drift off to sleep while listening to soothing recorded sounds that mimic six natural soundscapes: Rain, Ocean, Brook, Summer Night, Thunder and White Noise. This white noise machine is lightweight and portable and can be plugged into a wall outlet or powered by four AA batteries (not included). Prime Day price: $19.99, a savings of 20% for Prime members. Save an additional 30% on this item at checkout. Buy White Noise Sound Machine on Amazon.com Ergonomic Foot Rest Improve your posture and foot circulation during extended periods of sitting, with this adjustable under-desk foot rest. The surface is molded to provide stability and to massage pressure points on your feet, while 5 angles and heights allow you to customize the position for maximum comfort. Prime Day price: $21.59, a savings of 20% for Prime members Buy Ergonomic Foot Rest on Amazon.com Full Body Pillow The shape of this full body pillow provides support for back, knees and belly during pregnancy and post-surgery. Prime Day price: $43.19, a savings of 20% for Prime members Buy Full Body Pillow on Amazon.com 23andMe DNA Test Investigate your genetic heritage by submitting a saliva sample that you collect with this kit at home. Results arrive in 6 to 8 weeks. Prime Day price: $99.99, a savings of 50% for Prime members Buy 23andMe DNA Test on Amazon.com Pet Fitness Robot This robot provides stimulation and exercise for your housebound pet, interacting with it through motion detection sensors, and dispensing treats. It also tracks their activity, so you can monitor your pet’s fitness. The robot “can hold up to tough chewers and can get a little wet,” according to the manufacturers. Prime Day price: $101.40, a savings of 40% for Prime members Buy Pet Fitness Robot on Amazon.com Fitness Activity Tracker  Track your heart rate, blood pressure, menstrual cycle and more with a waterproof Bluetooth fitness tracker, controlled by a smartphone running iOS 8.1 and Android 4.4 and above (not for PC, iPad or tablets).  Prime Day price: $36.79, a savings of 20% for Prime members Buy Fitness Activity Tracker on Amazon.com Gaiam Reversible Yoga Mat Available in 38 colorful patterns, this thick, reversible yoga mat is lightweight, nonslip and durable, and is suitable for yoga, pilates and other floor exercises. Prime Day price: $26.25, a savings of 25% for Prime members Buy Gaiam Reversible Yoga Mat on Amazon.com Insulated Squeeze Bottle This easy-to-clean bottle holds 17 ounces (0.5 liters) and has double-walled construction, to keep water cold longer. Prime Day price: $15.00, Prime members save an additional 20% at checkout Buy Insulated Squeeze Bottle on Amazon.com Personal Single-Serving Blender  Whip up smoothies, healthy shakes or even baby food with this portable, single-serving and BPA-free blender. Built-in lithium batteries charge via USB, and the blender can be used 10-15 times on a single charge. Prime Day price: $25.27, a savings of 21% for Prime members Buy Personal Blender  on Amazon.com Canine Genetic Test A simple DNA test will determine all of the breeds that make up your dog’s genetic heritage, and will also pinpoint their age. Prime Day price: $68.98, a savings of 31% for Prime members Buy Canine Genetic Test on Amazon.com Originally published on Live Science.last_img read more

Massive HumanSize Jellyfish Stuns Divers Off the Coast of England

first_img 15 of the Largest Animals of Their Kind on Earth In Photos: Spooky Deep-Sea Creatures Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndo A pair of divers swimming off the southwestern tip of England hit the jelly jackpot last week after crossing paths with a hulking barrel jellyfish (Rhizostoma pulmo) — a rarely seen species that can grow about as large as a full-grown human. Luckily, they filmed the whole thing. The divers — biologist Lizzie Daly and underwater cinematographer Dan Abbott — shared the encounter in a Facebook video posted Saturday (July 13) as part of the Wild Ocean Week campaign — a series of videos showcasing the oddities of the deep to help raise money for the United Kingdom’s Marine Conservation Society.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65946-human-size-jellyfish-found-in-uk.html?jwsource=cl已复制直播00:0000:3500:35  Daly and Abbott were diving off the coast of Cornwall, U.K., when they saw the giant jelly emerge from the murky water. Also called the dustbin-lid jellyfish, the species is characterized by eight puffy arms capped by stinging tentacles and a large, globular head that lends the creature its unglamorous nickname. Barrel jellyfish sometimes wash up on the shore, Daly told Vice, but it’s rare for a diver to swim face-to-faceless-head with one of the massive blobs. [Marine Marvels: Spectacular Photos of Sea Creatures] While the barrel jellyfish is the largest species of jelly found in U.K. waters, it’s a mere shrimp when compared to the lion’s mane jellyfish (Cyanea capillata), the largest known species in the world. This coldwater jelly is known for its galaxy of 1,200 long, trailing tentacles, which can bring an individual creature’s total body length to up to 120 feet (36.5 meters) — which is longer than the average blue whale. This tangle of tentacles is so massive that a single lion’s mane jelly may be able to sting 50 to 100 people in just a few minutes if currents carry the jelly too close to a populated coast — a fun fact that a group of unlucky New Hampshire beachgoers learned the hard way in 2010. Dangers in the Deep: 10 Scariest Sea Creatureslast_img read more

Nikah halala petitioner seeks protection from SC after acid attackNikah halala petitioner

first_imgcourts and legal triple talaq gender COMMENT ANALYSISTriple talaq ruling: BJP scores, yet again Published on SHARE SHARE EMAIL September 14, 2018 RELATED The Supreme Court Friday agreed to hear on September 17 a plea filed by a petitioner in nikah halala and triple talaq case, seeking protection after facing acid attack yesterday at Bulandshahr in Uttar Pradesh.A bench of Chief Justice Dipak Misra and Justices A M Khanwikar and D Y Chandrachud considered the plea of Shabnam Rani, who was attacked allegedly by her brother-in-law and has been hospitalised. She has also sought better health care.The court asked advocate Ashwini Kumar Upadhyay, counsel for Rani, to submit a copy of the petition to the Centre and the Uttar Pradesh government.Numerous petitions have been filed in the apex court challenging the prevalent practices of nikah halala and polygamy among Muslims saying it was violative of fundamental rights guaranteed under the Constitution.While polygamy allows a Muslim man to have four wives, ‘nikah halala’ deals with the process in which a Muslim woman, who wants to re-marry her husband after divorce, has to first marry another person and get a divorce from the second person after the consummation.In her plea against nikah halala and polygamy, Rani had alleged that her husband divorced giving her triple talaq and forced to perform nikah hala with her brother-in-law. SHARE crime, law and justice COMMENTSlast_img read more

AP to hand over buildings inHyderabad to Telangana

first_imgSHARE SHARE EMAIL COMMENT Andhra Pradesh Telangana Governor ESL Narasimhan has ordered the handover of all but two government buildings in possession of the Andhra Pradesh government in Hyderabad to Telangana. The move comes within days of YS Jagan Mohan Reddy assuming office as Chief Minister after a resounding electoral victory and recent talks with his Telangana counterpart K Chandrasekhar Rao. Telangana request The Telangana Cabinet chaired by Chief Minister K Chandrasekhar Rao passed a resolution on Sunday, requesting the Governor to prevail upon AP government to hand over the buildings which were in the possession of AP, but not being used. Later in the evening, the Governor taking on record the request made by Telangana and the resolutions, called upon it to waive all outstanding claims of property tax and other charges on AP and allocated them to Telangana. Sevaral buildings in Hyderabad, including some of the buildings in State Secretariat were transferred to AP after the bifurcation of the State based on the AP Reorganisation Act. AP was entitled to have possession of these properties till 2024, as Hyderabad could serve as a capital of both States till then.However, with the Chandrababu Naidu government shifting its base to Amaravati more than a year ago, these unused buildings remained in the possession of AP. AP to get 2 buildings The AP government may be allotted a building to accommodate its police establishment and another for other administrative requirements in Hyderabad. The Governor’s order came after Rao met him and handed over the resolution passed by the Council of Ministers earlier in the day. After the bifurcation of AP in 2014, the assets were allocated in the population ratio of 52:48 to AP and TS. With the AP Capital now in Amaravati, and change of government, the process of handing over assets passed off smoothly. Cordial tiesLater, in a statement, Rao hoped that both the State governments would work in tandem in a give-and-take relationship, keeping in mind the realities on the ground. “My aim and ambition is to see both the States develop with its people living in peace and prosperity and all issues between the States be resolved amicably,” he said. 2 buildings may be retainedcenter_img June 03, 2019 Published on SHARE COMMENTSlast_img read more